Viral hepatitis in solid organ transplantation.

Viral hepatitis in solid organ transplant recipients.

Hepatotropic viral infections are frequent in allograft recipients and may be caused by a number of different viruses. Of these, the most important infectious agents are hepatitis B virus (HBV) and hepatitis C virus (HCV), which can cause both acute and chronic hepatitis. In addition, Hepatitis E virus (HEV), thought previously to only cause acute hepatitis in the developing world, is emerging ...

Viral Hepatitis in Non-Hepatic Solid Organ Transplant Recipients

Acute liver failure secondary to opportunistic viral infection in adult solid organ transplant recipients.

Acute liver failure (ALF) is the product of a rapid, overwhelming insult to the liver that destroys parenchymal function, resulting in a multisystem illness characterized by coagulopathy and encephalopathy. Viral infections and drug induced liver injury are the most common causes of ALF. The most common viral precipitants are the hepatotropic viruses, hepatitis A, B and E (ALF due to hepatitis ...

The Novel Immunosuppressive Protein Kinase C Inhibitor Sotrastaurin Has No Pro-Viral Effects on the Replication Cycle of Hepatitis B or C Virus

The pan-protein kinase C (PKC) inhibitor sotrastaurin (AEB071) is a novel immunosuppressant currently in phase II trials for immunosuppression after solid organ transplantation. Besides T-cell activation, PKC affects numerous cellular processes that are potentially important for the replication of hepatitis B virus (HBV) and hepatitis C virus (HCV), major blood-borne pathogens prevalent in soli...

Hepatitis E: when to treat and how to treat.

HEV generally causes a self-limited acute infection and treatment remains supportive. However, severe hepatitis or fulminant hepatic failure may occur, more so during pregnancy. It is an important cause of acute-on-chronic liver failure in endemic areas. Chronic HEV infection and progressive disease has been reported in recipients of solid organ transplants, haematological malignancies, HIV pat...